Abstract – Degradation failure is one of the main reasons for complex mechanical systems losing their functions. Research on multidisciplinary design optimization under uncertainties should shift from static uncertainties to time-varying uncertainties. Aiming at time-varying uncertainties in mechanical systems, we put forward a multidisciplinary reliability design optimization method using stochastic process theory. First, we investigated the characteristics of time-varying uncertainties in complex mechanical systems, and then utilized stochastic process theory to quantify time-varying uncertainties. Second, through combining the multidisciplinary simultaneous analysis and design optimization method, the model of multidisciplinary design optimization under time-varying uncertainties is established. Moreover, a mathematical problem and an engineering example are provided to illustrate the accuracy and effectiveness of the proposed method.